| # | Name | Origin | Meaning | Gender | |
|---|---|---|---|---|---|
| 541 | Sener | Anglo-Saxon | Fierce stronghold. | M | |
| 542 | Sever | Anglo-Saxon | Fierce stronghold. | M | |
| 543 | Seward | Anglo-Saxon | Sea guardian; guards the coast. | M | |
| 544 | Sheldon | Anglo-Saxon | From the hill on the ledge. | M | |
| 545 | Shelley | Anglo-Saxon | From the ledge meadow. | F | |
| 546 | Shelley | Anglo-Saxon | From the ledge meadow. | M | |
| 547 | Shelly | Anglo-Saxon | From the ledge meadow. | F | |
| 548 | Shelny | Anglo-Saxon | From the ledge farm. | M | |
| 549 | Shepard | Anglo-Saxon | Shepherd. | M | |
| 550 | Shephard | Anglo-Saxon | Shepherd. | M | |
| 551 | Sheply | Anglo-Saxon | From the sheep meadow. | M | |
| 552 | Sherard | Anglo-Saxon | Of glorious valor. | M | |
| 553 | Sherwin | Anglo-Saxon | Quick as the wind. | M | |
| 554 | Sherwyn | Anglo-Saxon | Quick as the wind. | M | |
| 555 | Sibley | Anglo-Saxon | Fiendly. | F | |
| 556 | Sigenert | Anglo-Saxon | Name of a king. | M | |
| 557 | Sihtric | Anglo-Saxon | Name of a king. | M | |
| 558 | Silver | Anglo-Saxon | White. | F | |
| 559 | Sinley | Anglo-Saxon | Friendly. | M | |
| 560 | Slean | Anglo-Saxon | Strikes. | M | |