| # | Name | Origin | Meaning | Gender | |
|---|---|---|---|---|---|
| 501 | Rufina | Italian | Red haired. | F | |
| 502 | Ruggero | Italian | Italian form of Roger 'famous spear'. | M | |
| 503 | Sabrina | Italian | From the border. | F | |
| 504 | Sal | Italian | Diminutive of Salvatore: Savior. | M | |
| 505 | Salvatore | Italian | Savior. Famous Bearer: Surrealist artist Salvador Dali. | M | |
| 506 | Salvatorio | Italian | Savior. | M | |
| 507 | Sancia | Italian | Holy. | F | |
| 508 | Sandro | Italian | Abbreviation of Alexander 'defender of man.'. | M | |
| 509 | Santino | Italian | Little saint. | M | |
| 510 | Santo | Italian | Sacred. | M | |
| 511 | Savino | Italian | Of the Sabines. | M | |
| 512 | Sebastiana | Italian | Feminine form of Sebastiano: revered. | F | |
| 513 | Sebastiano | Italian | Italian form of Sebastian 'revered'. | M | |
| 514 | Sebastiene | Italian | Feminine form of Sebastiano: revered. | F | |
| 515 | Serafina | Italian | From the seraph. | F | |
| 516 | Serena | Italian | Serene. | F | |
| 517 | Sergio | Italian | Attendant. | M | |
| 518 | Silvio | Italian | Silver. | M | |
| 519 | Simona | Italian | Italian form of Simone: one who hears. | F | |
| 520 | Speranza | Italian | Hope. | F | |