| # | Name | Origin | Meaning | Gender | |
|---|---|---|---|---|---|
| 541 | Servilius | Shakespearean | 'The Life of Timon of Athens' | M | |
| 542 | Sextus | Shakespearean | Antony and Cleopatra'. Sextus Pompeius, Roman triumvir. | M | |
| 543 | Seyton | Shakespearean | 'The Tragedy of Macbeth' Attendant to Macbeth. | M | |
| 544 | Shadow | Shakespearean | 'King Henry IV, Part 2' Simon Shadow, a country soldier. | M | |
| 545 | Shallow | Shakespearean | 'King Henry IV, Part 2' and 'The Merry Wives of Windsor' Robert Shallow, a country justice. | M | |
| 546 | Shepherd | Shakespearean | 'The Winter's Tale' The reputed father of Perdita is an old shepherd in the play. | M | |
| 547 | Shrewsbury | Shakespearean | 'Henry VI, Part 1' Lord Talbot, afterwards Earl of Shrewsbury. | M | |
| 548 | Shylock | Shakespearean | 'The Merchant of Venice' A rich Jew who loans money to Antonio. | M | |
| 549 | Sicinius | Shakespearean | 'The Tragedy of Coriolanus.' Sicinius Velutus, Tribune of the People. | M | |
| 550 | Silence | Shakespearean | 'King Henry IV, Part 2' A country justice. | M | |
| 551 | Silius | Shakespearean | Antony and Cleopatra'. An officer in Ventidius's army. | M | |
| 552 | Silvia | Shakespearean | 'Two Gentlemen of Verona' The Duke's daughter, beloved of Valentine. | F | |
| 553 | Silvius | Shakespearean | As You Like It' A shepherd. | M | |
| 554 | Simon | Shakespearean | 'King Henry IV, Part 2' Simon Shadow, a country soldier. | M | |
| 555 | Simonides | Shakespearean | 'Pericles, Prince of Tyre' Simonides, King of Pentapolis. | M | |
| 556 | Simpcox | Shakespearean | 'Henry VI, Part 2' Saunder Simpcox, an impostor. | M | |
| 557 | Simple | Shakespearean | 'The Merry Wives of Windsor' Servant to Slender. | M | |
| 558 | Siward | Shakespearean | 'The Tragedy of Macbeth' Siward, Earl of Northumberland, general of the English forces. Also Young Siward, his son. | M | |
| 559 | Slender | Shakespearean | 'The Merry Wives of Windsor' Cousin to Shallow. | M | |
| 560 | Sly | Shakespearean | 'King Richard III' Christopher Urswick, a priest. 'The Taming of the Shrew' Christopher Sly, a tinker. | M | |