| # | Name | Origin | Meaning | Gender | |
|---|---|---|---|---|---|
| 421 | Roger | Shakespearean | 'Henry VI, Part 2' Roger Bolingbroke, a conjurer. | M | |
| 422 | Romeo | Shakespearean | 'The Tragedy of Romeo And Juliet' Son to Montague, who falls in love with Juliet, the daughter to Capulet. | M | |
| 423 | Ross | Shakespearean | 'The Tragedy of Macbeth' A nobleman of Scotland. 'King Richard The Second' Lord Ross. | M | |
| 424 | Rotherham | Shakespearean | 'King Richard III' Thomas Rotherham, Archbishop of York. | M | |
| 425 | Rugby | Shakespearean | 'The Merry Wives of Windsor' Servant to Doctor Caius. | M | |
| 426 | Rumour | Shakespearean | 'King Henry IV, Part 2' The play's presenter. | M | |
| 427 | Rutland | Shakespearean | 'King Henry IV, Part 1' Earl of March. Scroop. 'King Henry the Sixth, Part III' Edmund, Earl of Rutland and son to Richard Plantagenet. | M | |
| 428 | Salerio | Shakespearean | 'The Merchant of Venice' Friend to Antonio and Bassanio. | M | |
| 429 | Salisbury | Shakespearean | 'Henry VI, Part 1' and 'Henry VI, Part 2' Earl of Salisbury. 'King Henry the Sixth, Part III' and 'King John' Earl of Pembroke. 'King Richard The Second' Earl of Salisbury. | M | |
| 430 | Salisbury M | Shakespearean | 'King Henry V' Earl of Salisbury. | M | |
| 431 | Sampson | Shakespearean | 'The Tragedy of Romeo And Juliet' Servant to Capulet. | M | |
| 432 | Sandys | Shakespearean | 'King Henry the Eighth' Lord Sandys. | M | |
| 433 | Saturninus | Shakespearean | 'The Tragedy of Titus Andronicus' Son to the late Emperor of Rome, and afterwards Emperor. | M | |
| 434 | Saunder | Shakespearean | 'Henry VI, Part 2' Saunder Simpcox, an impostor. | M | |
| 435 | Say | Shakespearean | 'Henry VI, Part 2' Lord Say. | M | |
| 436 | Scales | Shakespearean | 'Henry VI, Part 2' Lord Scales. | M | |
| 437 | Scarus | Shakespearean | Antony and Cleopatra'. Friend to Mark Antony. | M | |
| 438 | Scroop | Shakespearean | 'King Richard The Second' Sir Stephen Scroop. | M | |
| 439 | Sebastian | Shakespearean | 'Twelfth Night', also called 'What You Will' Brother of Viola. 'The Tempest' Sebastian, brother to Alonso. | M | |
| 440 | Seleucus | Shakespearean | Antony and Cleopatra'. Attendant on Cleopatra. | M | |