| # | Name | Origin | Meaning | Gender | |
|---|---|---|---|---|---|
| 641 | Rosemarie | Spanish | Bitter. | F | |
| 642 | RosIyn | Spanish | Beautiful. | F | |
| 643 | Roslyn | Spanish | Variant of Rosalind: Beautiful; pretty rose. | F | |
| 644 | Rufa | Spanish | Red haired. | F | |
| 645 | Rufina | Spanish | Red haired. | F | |
| 646 | Sabana | Spanish | From the open plain. | F | |
| 647 | Sabina | Spanish | A Sabine. | F | |
| 648 | Sadie | Spanish | Diminutive of Mercedes: Mercy. Derived from one of the Spanish titles for the Virgin Mary (Maria de las Mercedes). | F | |
| 649 | Salbatora | Spanish | Savior. | F | |
| 650 | Salvadora | Spanish | Savior. | F | |
| 651 | Salvatora | Spanish | Savior. | F | |
| 652 | Sancha | Spanish | Holy. | F | |
| 653 | Sanchia | Spanish | Holy. | F | |
| 654 | Sancia | Spanish | Holy. | F | |
| 655 | Sara | Spanish | Princess. | F | |
| 656 | Sarita | Spanish | Princess. | F | |
| 657 | Saturnina | Spanish | Gift of Saturn. | F | |
| 658 | Savanna | Spanish | From the open plain. | F | |
| 659 | Savannah | Spanish | From the open plain. | F | |
| 660 | Segunda | Spanish | Born second. | F | |